Stem cell treatments for female reproductive disorders: a comprehensive review
Nair R., Agarwal P., Gadre MA., Vasanthan KS., Seetharam RN.
Narrative Review, published in J Ovarian Res (2025) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Narrative Review
- Journal
- J Ovarian Res (2025)
- Reported sample size
- —
- Source database
- Europe PMC
- PMID
- 40708035
- PMCID
- PMC12288315
- DOI
- 10.1186/s13048-025-01750-y
- Citations
- 2
Abstract (original English)
Stem cell research is advancing rapidly, offering substantial promise in reproductive medicine, particularly in addressing infertility and other reproductive disorders. Although recent advances have generated significant interest, the successful translation of stem cell treatments from preclinical research settings to clinical practice requires a comprehensive understanding of the underlying mechanisms and methodological approaches. This review assesses the current state of stem cell applications in the field of reproductive medicine, emphasizing current research and development, as well as the associated challenges. Adult stem cell-based interventions show considerable potential for treating reproductive tract disorders, mainly ovarian and endometrial regeneration. Despite these promising developments, the transition to widespread clinical implementation is hampered by several challenges, including its heavy reliance on preclinical animal data. The promise of stem cell therapy is considerable, however, validated mechanisms need to be developed that can fully harness their therapeutic capabilities in clinical settings. This review consolidates and evaluates the evidence regarding the therapeutic potential of various stem cell sources, emphasizing their benefits and drawbacks. Although stem zcell therapies have substantial potential for rejuvenating organ dysfunction, future res
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is a narrative review: it collects no new patient data and does not systematically appraise evidence quality.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
How we grade evidenceBrowse all related research
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