Structure and properties of porous films based on aliphatic copolyamide developed for cellular technologies.
Dobrovolskaya IP., Popryadukhin PV., Yudin VE., Ivan'kova EM., Elokhovskiy VY., Weishauptova Z.
Laboratory Study, published in J Mater Sci Mater Med (2015) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Laboratory Study
- Journal
- J Mater Sci Mater Med (2015)
- Country
- United States
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 25589206
- DOI
- 10.1007/s10856-015-5381-y
Abstract (original English)
The effect of concentration and viscosity of the copolyamide (copolymer of ε-caprolactam and hexamethylendiaminadipate) solutions in aqueous/alcoholic solvents on its phase state was studied. The films obtained by the coagulation method were characterized by monodisperse pore distribution with an average pore size of 1.3 μm. The films processed by electrospinning from copolyamide solutions were characterized by a bimodal distribution of macropores with one peak of pore radius at 2.0 μm and second peak of pore radius at 20 μm. The adhesion and proliferation of mesenchymal adhesion stem cells (ASCs) stem cells to copolyamide matrix were studied. With the help of scanning electron microscopy it was shown that both tapes porous films were characterized by good adhesion of mesenchymal ASCs stem cells. It was shown that the porous structure, transport and mechanical properties of these copolyamide films allow their use as two-dimensional matrices for cellular technology.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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