Submolecular modulation of PIEZO1 mechanotransduction with wireless tailor-made nanoswitches
Teixeira SPB., Pardo A., Taboada P., Bijonowski BM., Carvalho MT., Nieder JB.
Laboratory Study, published in Bioact Mater (2026) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Laboratory Study
- Journal
- Bioact Mater (2026)
- Reported sample size
- —
- Source database
- Europe PMC
- PMID
- 42088832
- PMCID
- PMC13137217
- DOI
- 10.1016/j.bioactmat.2026.03.051
Abstract (original English)
PIEZO mechanoreceptors play critical roles in fundamental physiological processes such as proprioception or musculoskeletal biomechanics. However, their complex gating mechanisms and downstream signaling are still not completely understood, mainly due to the lack of effective probing tools. Here, we combine molecular imprinting and magnetic concepts to develop tailor-made nanoswitches enabling wireless targeted actuation of PIEZO1. Two epitopes selected in silico from distinct domains of PIEZO1 were used as templates for synthesizing magnetically responsive molecularly imprinted nanoparticles. These nanoswitches showed sub-nanomolar affinity for their respective epitope and recognized PIEZO1 in endothelial cells, similarly to antibodies. Applying magnetic fields to actuate PIEZO1 through nanoswitches led to increased calcium signaling, Yes-associated protein (YAP) nuclear translocation, and significant changes in the expression of genes related to PIEZO1 activity, implying that they can transduce the stimulus into intracellular signaling effects. Finally, this wireless actuation system proved to be effective in differentially modulating the behavior of mesenchymal stem cells. Remarkably, the selective targeting of each epitope led to contrasting downstream signaling cascades, implying distinct roles for each superstructure domain in the sophisticated function of these channels.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
How we grade evidenceBrowse all related research
Filter the research library by this study's title keywords, author, or publication year.