SVF
Level D· Scientific groundwork from lab and animal studiesAnimal StudyPubMed

Surface functionalization of halloysite nanotubes with supermagnetic iron oxide, chitosan and 2-D calcium-phosphate nanoflakes for synergistic osteoconduction enhancement of human adipose tissue-derived mesenchymal stem

Lee YJ., Lee SC., Jee SC., Sung JS., Kadam AA.

Animal Study on Face & Skin, published in Colloids Surf B Biointerfaces (2018) — summary generated from the PubMed abstract.

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Level D· Scientific groundwork from lab and animal studiesEvidence level of this study

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

  • Level A · Stronger Clinical Evidence
  • Level B · Emerging clinical evidence with positive signals
  • Level C · Early human research exploring benefits
  • Level D · Scientific groundwork from lab and animal studies
  • Emerging · Emerging topic under active research
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This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.

Study type
Animal Study
Journal
Colloids Surf B Biointerfaces (2018)
Country
Netherlands
Reported sample size
—
Source database
PubMed
PMID
30261345
DOI
10.1016/j.colsurfb.2018.09.045

Abstract (original English)

Halloysite nanotubes (HNTs) are known to be the highly emerging materials in nano-medicinal applications. However, comprehensive exploitation of HNTs for the regenerative medicinal applications is still necessary to be done. Therefore, towards enhancing the osteogenic potential of human adipose tissue-derived mesenchymal stem cells (hADMSCs), this study synthesized a novel and multifunctional nanoscaffold of chitosan (CTs) functionalized supermagnetic halloysite nanotubes (M-HNTs) decorated with the calcium phosphate 2-D nanoflakes (CaP) (termed as; M-HNTs-CTs-CaP). Stepwise modified nanoscaffolds were characterized by FE-SEM, FE-SEM-EDS, FE-HR-TEM, XPS, FT-IR and VSM analyses. The hADMSCs osteogenic potential was confirmed by calcification (Alizarin Red S staining), phosphate quantification and immunocytochemistry. Nanoscaffolds; CaP, M-HNTs-CaP and M-HNTs-CTs-CaP were significantly enhanced and up-regulated osteogenic potential compared to the HNTs, M-HNTs, M-HNTs-CTs. Among the nanoscaffolds studied, M-HNTs-CTs-CaP exhibited highest osteogenesis, due to the enhanced CaP distribution on M-HNTs-CTs surface, and synergistic osteoconduction contributed from Fe 3 O 4 , chitosan and CaP. Moreover, immunocytochemistry analysis and morphologically observation showed well differentiated osteoblast on the M-HNTs-CTs-CaP surface. Therefore, M-HNTs-CTs-CaP found to have a strong osteoge

What this study does not prove

  • • This study does not prove SVF is an approved treatment or a replacement for standard care.
  • • This is preclinical work; animal or laboratory results cannot be applied to humans.

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

How we grade evidence
Adipose TissueAnimalsBone RegenerationBone and BonesCalcification, PhysiologicCalcium PhosphatesCell DifferentiationChitosanClayHumans
Face & Skin
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