SVF
Level D· Scientific groundwork from lab and animal studiesLaboratory StudyPubMed

Surface proteins and osteoblast markers: characterization of human adipose tissue-derived osteogenic cells.

Trentz OA., Arikketh D., Sentilnathan V., Hemmi S., Handschin AE., de Rosario B.

Laboratory Study on Face & Skin, published in Eur J Trauma Emerg Surg (2010) — summary generated from the PubMed abstract.

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Level D· Scientific groundwork from lab and animal studiesEvidence level of this study

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

  • Level A · Stronger Clinical Evidence
  • Level B · Emerging clinical evidence with positive signals
  • Level C · Early human research exploring benefits
  • Level D · Scientific groundwork from lab and animal studies
  • Emerging · Emerging topic under active research
Read the A–D evidence level guide

This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.

Study type
Laboratory Study
Journal
Eur J Trauma Emerg Surg (2010)
Country
Germany
Reported sample size
—
Source database
PubMed
PMID
26816227
DOI
10.1007/s00068-010-0030-0

Abstract (original English)

In adipose tissue-derived osteogenic cells (ADOC), osteoblast markers and surface proteins were determined and compared with osteoblasts harvested from cancellous bone (OB). Osteocalcin (OC), core binding factor 1 (CBFA1), collagen type 1 (Coll1), alkaline phosphatase (ALP), nucleostemin (NS), and surface proteins CD 10, CD44, CD 59 and CD 105 were analyzed using RT-PCR, immunofluorescence and Western blot. Osteocalcin expression was more distinct in OB than in ADOC, but the other markers and surface proteins showed no differences. These data support the use of adipose tissue for future regenerative medicine; however, further studies are necessary to establish the role of long-term differentiation.

What this study does not prove

  • • This study does not prove SVF is an approved treatment or a replacement for standard care.
  • • This is preclinical work; animal or laboratory results cannot be applied to humans.

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

How we grade evidence
Face & Skin
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