[Switching of osteoblastogenesis versus adipogenesis].
Takada I.
Narrative Review, published in Clin Calcium (2012) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Narrative Review
- Journal
- Clin Calcium (2012)
- Country
- Japan
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 22549186
Abstract (original English)
To maintain a balance between the differentiation of adipocytes and osteoblasts is one of significant issues related to osteoporosis and metabolic syndrome. Both adipocytes and osteoblasts are derived from mesenchymal stem cells and recent studies have shown that osteoblast or adipocyte differentiation regulators reciprocally control each cell differentiations. In particular, PPAR-gamma plays a pivotal role for adipocyte differentiation and directly controls the differentiation of osteoblast and osteoclast. In this report, I summarize recent researches mainly focusing on the transcriptional co-regulators and extracellular signals regulating the transactivation function of PPAR-gamma.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is a narrative review: it collects no new patient data and does not systematically appraise evidence quality.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
How we grade evidenceBrowse all related research
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