Synergistic Effects of Thread Lifting, Autologous Fat Grafting, and Multi-Modal Laser Therapy in Facial Rejuvenation

Early human evidence such as case series or small samples is exploring possible benefits.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Background Facial aging is a multifactorial process involving tissue descent, volume depletion, and dermal degeneration. Minimally invasive modalities like thread lifting, autologous fat grafting, and laser treatments address different aging components. However, their synergistic impact remains underexplored. Objectives The aim of the author of this study is to assess the clinical efficacy and histologic rationale of combining permanent thread lifting, autologous fat grafting, and nonablative laser therapy for comprehensive facial rejuvenation. Methods In this retrospective study, a total of 65 female patients (aged 31-60, Fitzpatrick skin types II-IV) treated from January 2022 to January 2023 were included. Patients were divided into 3 groups: thread lifting alone (Group 1), thread + laser (Group 2), and thread + laser + fat grafting (Group 3). Evaluations were performed at 12 months by a plastic surgeon, a dermatologist, and the patients themselves using a 5-point Likert-scale assessing skin texture, fine wrinkles, lift effect, and overall satisfaction. Kruskal-Wallis and Mann-Whitney U tests with Bonferroni correction were utilized, alongside cumulative link regression models. Results Significant group differences were observed in skin texture ( P = .00013) and overall satisfaction ( P = .00421). Post hoc comparisons revealed that Groups 2 and 3 outperformed Group 1 in skin

Evidence level

Early human evidence such as case series or small samples is exploring possible benefits.

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