The Synthesis of Europium-Doped Calcium Carbonate by an Eco-Method as Free Radical Generator Under Low-Intensity Ultrasonic Irradiation for Body Sculpture
Kuan CY., Lin YY., Yang IH., Chen CY., Chi CY., Li CH.
Animal Study, published in Front Bioeng Biotechnol (2021) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Animal Study
- Journal
- Front Bioeng Biotechnol (2021)
- Reported sample size
- —
- Source database
- Europe PMC
- PMID
- 34869278
- PMCID
- PMC8639516
- DOI
- 10.3389/fbioe.2021.765630
- Citations
- 5
Abstract (original English)
Body sculpture is a common method to remove excessive fat. The diet and exercise are the first suggestion to keep body shape; however, those are difficult to keep adherence. Ultrasound has been developed for fat ablation; however, it could only serve as the side treatment along with liposuction. In the study, a sonosensitizer of europium-doped calcium carbonate (CaCO 3 : Eu) would be synthesized by an eco-method and combined with low-intensity ultrasound for lipolysis. The crystal structure of CaCO 3 : Eu was identified by x-ray diffractometer (XRD). The morphology of CaCO 3 : Eu was analyzed by scanning electron microscope (SEM). The chemical composition of CaCO 3 : Eu was evaluated by energy-dispersed spectrophotometer (EDS) and inductively coupled plasma mass spectrometer (ICP-MS). The electronic diffraction pattern was to further check crystal structure of the synthesized individual grain by transmission electron microscope (TEM). The particle size was determined by Zeta-sizer. Water-soluble tetrazolium salt (WST-1) were used to evaluate the cell viability. Chloromethyl-2',7'-dichlorofluorescein diacetate (CM-H 2 DCFDA) and live/dead stain were used to evaluate feasibility in vitro . SD-rat was used to evaluate the safety and efficacy in vivo . The results showed that CaCO 3 : Eu had good biocompatibility and could produce reactive oxygen species (ROS) after treated with lo
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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