A Systematic Review of Adipose-Derived Cell Therapies on Skin Quality.

Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Skin aging leads to changes such as dyschromia, rhytids, dermal atrophy, and reduced elasticity. Adipose-derived cell therapies (ADCTs), including stromal vascular fraction (SVF), adipose-derived stem cells (ADSCs), and adipose-derived mesenchymal stem cells (AD-MSCs), have gained attention for their regenerative potential. In this systematic review, the authors aim to evaluate the effectiveness of ADCT in improving skin quality such as elasticity, texture, pigmentation, and rhytid reduction. This systematic review was conducted following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, with a comprehensive search conducted across PubMed (National Library of Medicine, Bethesda, MD), Embase (Elsevier, Amsterdam, the Netherlands), and Scopus (Elsevier). The authors of eligible studies must have assessed skin quality outcomes, such as rhytids, dyschromia, texture, and elasticity. Data on study design, treatment protocols, and outcomes were extracted. Risk of bias was assessed using the Cochrane RoB 2 tool (Cochrane, London, United Kingdom). Meta-analyses were conducted where appropriate. Seventeen studies met inclusion criteria. Rhytid severity decreased with SVF and ADSC-conditioned medium, particularly in periorbital and nasolabial regions. However, the authors of a meta-analysis of 2 studies showed nonsignificant reduction in rhytids ( P = .12, I 2

Evidence level

Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.

Browse all related research

Filter the research library by this study's title keywords, author, or publication year.