A systematic review of the biomechanical and biological impacts of ultrasound waves on skeletal tissues
Montazeri A., Esnaasharieh M., Hajizadeh R.
Systematic Review, published in Biomed Eng Online (2026) — summary generated from the PubMed abstract.
Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Systematic Review
- Journal
- Biomed Eng Online (2026)
- Reported sample size
- —
- Source database
- Europe PMC
- PMID
- 41721336
- PMCID
- PMC12924520
- DOI
- 10.1186/s12938-026-01517-6
- Citations
- 1
Abstract (original English)
Introduction Ultrasound waves can affect bone and bone marrow, and widespread medical and industrial use increases the likelihood of direct or indirect exposure. This systematic review summarizes current evidence on the biological and biomechanical effects of high- and low-intensity ultrasound on skeletal tissues, with emphasis on safety. Methods A systematic search was conducted across PubMed, ScienceDirect, Wiley Online Library, EMBASE, JSTOR, IEEE Xplore, Scopus, and Google Scholar (up to October 2024), guided by a PICO-based strategy. Studies were screened using predefined eligibility criteria, and 29 articles met the inclusion criteria for synthesis. Study quality was appraised using the Newcastle-Ottawa Scale (NOS) and the 2018 Mixed Methods Appraisal Tool (MMAT). The protocol was registered in PROSPERO (CRD42024620731). Results Ultrasound technology has significant implications for health and safety due to its medical and industrial applications. High-intensity ultrasound waves may cause tissue damage, reduce bone density, and even lead to necrosis. However, controlled low-intensity ultrasound can be beneficial in medical treatments and tissue healing. Conclusions To minimize potential risks, it is crucial to establish safety standards and enhance public awareness regarding the appropriate use of ultrasound technology. In summary, while prolonged exposure to ultrasound m
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
Evidence level
Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.
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