A Systematic Review and Integrated Bioinformatic Analysis on the Gene Expression of Cumulus-Oocyte Complex Following In Vitro Maturation
Elias MH., Zainal N., Abdul Rahman SN., Sutaji Z., Ahmad MF., Mohd Manzor NF.
Systematic Review, published in Malays J Med Sci (2025) — summary generated from the PubMed abstract.
Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Systematic Review
- Journal
- Malays J Med Sci (2025)
- Reported sample size
- —
- Source database
- Europe PMC
- PMID
- 41081025
- PMCID
- PMC12513515
- DOI
- 10.21315/mjms-12-2024-948
Abstract (original English)
Infertility, a rising global concern, is frequently caused by genetic causes, making modern reproductive methods like in vitro fertilisation (IVF) and in vitro maturation (IVM) necessary for successful conception. Nonetheless, little is known about the molecular pathways causing infertility. This study conducted a systematic review following PRISMA guidelines, aiming to comprehensively elucidate the gene expression profiles of cumulus cells following IVM and their implications for reproductive outcomes. A thorough literature search was conducted across multiple databases, employing a combination of keywords related to cumulus cells, IVM, and gene expression. For this systematic review, screening processes identified four clinical human studies meeting inclusion criteria, published between 2013 and 2022. The studies used qPCR and RNA sequencing to compare gene expression in cumulus cells pre- and post-IVM or between IVF and IVM patients. Despite variations in sample sizes and methodologies, 22 differentially expressed genes (DEGs) were identified, with 10 common DEGs between IVF and IVM matured cumulus-oocyte complexes. Protein-protein interaction network analysis revealed a complex molecular network associated with cumulus cell function and oocyte maturation. Clustering analysis identified a significant cluster enriched in genes involved in the epidermal growth factor receptor
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
Evidence level
Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.
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