A systematic review of therapeutic procedures for the treatment of morphea and systemic sclerosis.

Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Considering the challenges involved in managing morphea and systemic sclerosis—especially the risks of disease reactivation and inflammation following treatment—and the limited evidence on the effectiveness and safety of treatment methods like energy-based devices and intralesional injections, it is essential to conduct a systematic review to compile and critically evaluate the available data comprehensively. This review aims to evaluate the effectiveness and safety of energy-based devices and intralesional injections in managing morphea and systemic sclerosis, to provide critical evidence that informs clinical decision-making and ultimately enhances patients’ quality of life. This study was conducted as a systematic review following established guidelines and checklists for such reviews. The PRISMA flow diagram was employed to illustrate the identification, screening, eligibility, and inclusion of studies. Comprehensive searches were performed from different scientific databases, including PubMed, Scopus, Web of Science, and Embase, to identify all relevant studies evaluating the effectiveness and safety of energy-based devices and intralesional injections in treating morphea and systemic sclerosis. We managed the retrieved records using EndNote reference management software. After a thorough screening process, we extracted relevant data based on predefined study variables and

Evidence level

Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.

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