Systematic review on utility of stem-cell engineering on outcome of oral and maxillofacial prosthesis (rehabilitation).

Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Oral and maxillofacial (OMF) defects present complex clinical challenges, often requiring advanced reconstructive techniques. Stem-cell-based tissue engineering, particularly using mesenchymal stem cells (MSCs), has emerged as a promising alternative for OMF rehabilitation, offering the potential for tissue regeneration and modulation of healing responses. A comprehensive literature search was conducted in PubMed, Scopus, and Web of Science databases to identify relevant studies published between 2014 and 2024. Studies included focused on the application of stem cells, scaffolds, and biomaterials in the regeneration of OMF tissues. Eligibility criteria included clinical trials, observational studies, reviews, and case series involving human, animal, or in vitro models related to OMF defects. A total of 10 studies met the inclusion criteria, encompassing a range of methodologies and stem cell types, such as dental MSCs, adipose-derived stem cells (ADMSCs), and bone marrow stem cells (BMSCs). Key findings indicate that MSCs, when combined with advanced biomaterials and scaffold technologies, significantly enhance tissue regeneration and functional restoration in OMF reconstruction. However, challenges such as achieving vascularization and long-term viability of engineered tissues, as well as standardization of treatment protocols, remain significant barriers to clinical translati

Evidence level

Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.

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