T-PRP-DAT Gel: A Novel Material Promotes Adipose Tissue Regeneration.
Hou M., Tang J., Guo Y., Peng H., Liang B., Cheng Y.
Animal Study, published in J Cosmet Dermatol (2025) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Animal Study
- Journal
- J Cosmet Dermatol (2025)
- Country
- England
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 39963070
- PMCID
- PMC11833427
- DOI
- 10.1111/jocd.70045
- Citations
- 1
Abstract (original English)
Background Decellularized adipose tissue (DAT) has emerged as a promising tissue-specific regenerative platform for soft tissue augmentation and reconstruction. Hydrogels are a widely used DAT scaffold format for their injectability and porous structure. While unstable structure and poor vascularization limit the adipose tissue regeneration of DAT gels, this yields significant clinical necessity for solutions to this problem. Methods Based on collagen-fibrin interpenetrating, we developed an injectable thermosensitive DAT/PRP interpenetrating polymer network (t-DP gel/t-DPI) with the composition of DAT and temperature-controlled platelet-rich plasma (t-PRP). The same volume of t-DP gel and DAT gel were transplanted in a mouse model, and graft volume, weight, adipose tissue regeneration rate, and vascularization were compared. Results The t-DPI showed reinforced stability for the interpenetrating polymer network (IPN) of collagen-fibrin and sustained release of growth factors from the t-PRP, resulting in improved graft volume, weight, adipose tissue regeneration, and vascularization. Conclusions Compared with traditional DAT gel, t-DP gel promotes adipose tissue regeneration by promoting angiogenesis and stability, and t-DP gel has great potential for future applications in the field of plastic surgery for its simple preparation and regeneration ability.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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