Tart cherries (<i>Prunus cerasus</i>) and metabolic health in overweight and obesity: evidence from preclinical and clinical studies

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Overweight and obesity remain major global health challenges and are closely associated with metabolic disturbances, including dyslipidemia, insulin resistance, hypertension, and chronic low-grade inflammation. Dietary patterns rich in fruits and vegetables contribute to metabolic health, partly due to their complex matrix of bioactive compounds. Tart cherries ( Prunus cerasus , TC) are widely consumed in fresh and processed forms and have attracted attention for their potential benefits in obesity-related conditions. This review critically summarizes current evidence from in vitro , animal, and human studies investigating the effects of tart cherries and their derived products in overweight and obese individuals (BMI ≥ 25 kg/m 2 ). Animal studies consistently reported anti-inflammatory, antioxidant, and metabolic improvements following tart cherry supplementation. In humans, the evidence suggested potential benefits for blood pressure and selected inflammatory markers, whereas findings regarding lipid profile, glucose metabolism, and body composition remain inconsistent. Overall, tart cherries may favorably influence metabolic and vascular processes associated with obesity; however, heterogeneity in study design, dosage, and product form limits definitive conclusions. Further research should focus on identifying the key bioactive components, understanding their bioavailability

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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