Therapeutic applications of miRNA in the management of obesity and osteoporosis.

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Obesity and osteoporosis are interrelated global health challenges, both characterized by dysregulated bone metabolism and adipose tissue dynamics, contributing to increased fracture risk and systemic complications. Emerging evidence underscores the pivotal role of microRNAs (miRNAs) as regulatory molecules governing the intricate balance between adipogenesis and osteogenesis, thereby providing a molecular link between these two conditions. Both disorders are characterized by intricate alterations in bone metabolism and adipose tissue dynamics, which increase the risk of fractures and systemic complications. Recent advancements in molecular biology have identified miRNAs as crucial regulators of these disorders, influencing the differentiation of bone marrow mesenchymal stem cells (BMSCs) into osteoblasts (bone-forming cells) and adipocytes (fat-storing cells). This review provides a comprehensive analysis of the dual role of miRNAs in modulating osteogenesis and adipogenesis, with a particular focus on their implications in disease progression and therapeutic strategies. It first explores how specific miRNAs regulate critical energy metabolism, inflammation, and bone remodeling pathways. By integrating insights from molecular biology, endocrinology, and clinical practice, the review highlights the therapeutic potential of miRNA-based interventions. Targeting specific miRNAs co

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

Browse all related research

Filter the research library by this study's title keywords, author, or publication year.