Therapeutic effects of Eucommia ulmoides extract on osteoporosis rat models: a systematic review and meta-analysis
Chen Z., Leng C., Rui T., Feng C., Li T., Yu Y.
Meta-analysis, published in Front Pharmacol (2025) — summary generated from the PubMed abstract.
Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Meta-analysis
- Journal
- Front Pharmacol (2025)
- Reported sample size
- —
- Source database
- Europe PMC
- PMID
- 41059187
- PMCID
- PMC12497778
- DOI
- 10.3389/fphar.2025.1619687
Abstract (original English)
Background Eucommia ulmoides Oliv. Is a plant in the family Eucommiaceae and genus Eucommia. For thousands of years, it has been one of the most frequently used botanical medicines. Recent research has highlighted the therapeutic effects of its extracts for osteoporosis. However, its benefits still need to be thoroughly analyzed. Objective This study aimed to systematically evaluate the efficacy of Eucommia ulmoides extract in osteoporotic rat models and explore its underlying mechanisms. Methods Following the PRISMA guidelines, a comprehensive literature search was conducted across PubMed, Web of Science, Embase, and four other databases. A total of 511 records were identified, and 18 randomized controlled trials (RCTs) were ultimately included. The risk of bias in the included studies was assessed using the SYRCLE tool. Data synthesis and statistical analyses were performed using Stata SE 18 and RevMan 5.4 software. Results E. ulmoides extract significantly improved bone mineral density (SMD = 2.44, 95% CI 1.83-3.05, p Conclusion E. ulmoides extract is an effective treatment for osteoporosis. It promotes bone formation, inhibits bone resorption, and improves bone microarchitecture. These findings support its potential as a plant-derived therapeutic agent for osteoporosis. Systematic review registration https://www.crd.york.ac.uk/PROSPERO/, identifier CRD420251003546.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
Evidence level
Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.
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