SVF
Level A· Stronger Clinical EvidenceSystematic ReviewPubMedOpen access

Therapeutic potential of dental mesenchymal stem cells versus mesenchymal stem cells from other sources: a systematic review of animal studies.

Daneshvar A., MomeniAmjadi A., Azadi A., Baniameri S., Kadkhodazadeh M.

Systematic Review with a reported sample of 29 on Ligament Injury, Immune Modulation, published in BMC Oral Health (2025) — summary generated from the PubMed abstract.

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Level A· Stronger Clinical EvidenceEvidence level of this study

Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.

  • Level A · Stronger Clinical Evidence
  • Level B · Emerging clinical evidence with positive signals
  • Level C · Early human research exploring benefits
  • Level D · Scientific groundwork from lab and animal studies
  • Emerging · Emerging topic under active research
Read the A–D evidence level guide

This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.

Study type
Systematic Review
Journal
BMC Oral Health (2025)
Country
England
Reported sample size
29
Source database
PubMed
PMID
41354918
PMCID
PMC12801836
DOI
10.1186/s12903-025-07100-0

Abstract (original English)

BACKGROUND: Stem cell-based therapy, a crucial area of regenerative medicine, aims to enhance the body’s repair mechanisms by stimulating, modulating, and regulating endogenous stem cells or replenishing cell pools, thereby promoting tissue homeostasis and regeneration and offering promising treatments for numerous systemic diseases. This systematic review comprehensively summarizes animal studies investigating the efficacy of dental mesenchymal stem cells (DMSCs) in treating systemic diseases and promoting tissue regeneration compared to mesenchymal stem cells (MSCs) derived from other sources. METHODS: PICO question was, “What is the difference in efficacy between dental-derived mesenchymal stem cells and mesenchymal stem cells from other sources when used for the treatment of systemic diseases and/or tissue regeneration?” A comprehensive search, up to October 2024, across PubMed, Embase, and Scopus was conducted using a defined search strategy to identify relevant studies. Controlled animal studies were included, and the risk of bias was assessed using the SYRCLE tool. RESULTS: This systematic review included 29 studies published between 2008 and 2024, comparing the therapeutic efficacy of various dental-derived stem cells, including DPSCs (Dental Pulp Stem Cells), DPNCCs (Dental Pulp Neural Crest Cells), GMSCs (Gingival Mesenchymal Stem Cells), SHEDs (Stem Cells from Human

What this study does not prove

  • • This study does not prove SVF is an approved treatment or a replacement for standard care.

Evidence level

Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.

How we grade evidence
AnimalsMesenchymal Stem Cell TransplantationMesenchymal Stem CellsDental PulpRegenerative MedicineHumansRegeneration
Systemic / IVLigament InjuryImmune Modulation
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