Thermally Conductive Biopolymers in Regenerative Medicine and Oncology: A Systematic Review
Poma-Paredes I., Vivanco-Galván O., Castillo-Malla D., Jiménez-Gaona Y.
Systematic Review, published in Pharmaceuticals (Basel) (2025) — summary generated from the PubMed abstract.
Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Systematic Review
- Journal
- Pharmaceuticals (Basel) (2025)
- Reported sample size
- —
- Source database
- Europe PMC
- PMID
- 41304953
- PMCID
- PMC12655858
- DOI
- 10.3390/ph18111708
- Citations
- 1
Abstract (original English)
Background: Minimally invasive hyperthermia and regenerative therapies require materials that deliver precise, localized heat without compromising biocompatibility. Most conventional polymers are thermally insulating and challenging to control in vivo, motivating this review. Objectives: We aimed to (i) examine the use of thermally enhanced biopolymers in hyperthermia-based therapies, (ii) appraise evidence from clinical and preclinical studies, (iii) identify and classify principal applications in regenerative medicine. Methods: A PRISMA-guided systematic review (2020-2025) with predefined inclusion/exclusion criteria was conducted and complemented by a bibliometric analysis using VOSviewer for mapping and visualization. Results: Modifying biopolymers-via functionalization with photothermal or magnetic nanoagents (Au; Fe 2 O 3 /Fe 3 O 4 /CoFe 2 O 4 ; CuS; Ag; MXenes, e.g., Nb 2 C), crosslinking strategies, and hybrid formulations-significantly increased thermal conductivity, enabling localized hyperthermia and controlled drug release. In vitro and in vivo studies showed that europium-doped iron oxide nanoparticles embedded in chitosan generated heat efficiently while sparing healthy tissues, underscoring the need to balance biocompatibility and thermal performance. Hydrogel systems enriched with carbon nanomaterials (graphene, carbon nanotubes) and matrices such as GelMA, PNIP
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
Evidence level
Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.
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