Thermoresponsive Complex Coacervates as Advanced Carriers for Cell-Laden Liquid-Core Capsules for Biomedical Applications.
Monteiro LPG., Carreira M., Es Sayed J., Kamperman M., Rodrigues JMM., Mano J.
Laboratory Study, published in Small (2026) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Laboratory Study
- Journal
- Small (2026)
- Country
- Germany
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 41988900
- PMCID
- PMC13244403
- DOI
- 10.1002/smll.202513642
Abstract (original English)
Injectable "smart" materials are emerging as promising platforms for minimally invasive cell delivery and tissue regeneration. A novel thermoresponsive complex coacervate was engineered through electrostatic interactions between natural polysaccharides grafted with poly(N-isopropylacrylamide) (PNIPAAm). The resulting biopolymeric-derived coacervate exhibits pronounced shear-thinning behavior and undergoes a rapid sol-gel transition at physiological temperature. Rheological analysis revealed that the thermoresponsive PNIPAAm chains regulate network dynamics, with faster relaxation at 25°C and enhanced structuring at 37°C due to increased hydrophobic interactions. The designed complex coacervate provides an efficient transport vehicle for the in situ retention of liquid-core capsules (LC) loaded with human adipose stem cells, promoting autonomous and hierarchical tissue organization. This system retained its shear-thinning properties even at high LC volumetric ratios (up to 54%) and supported high cell viability at least for 7 days. This strategy enables cell encapsulation in a thermoresponsive injectable complex coacervate that can be loaded with virtually any, or even multiple, cell types, offering a highly modular and cytocompatible platform. Altogether, this work introduces a new paradigm for the design of bioinspired, thermoresponsive complex coacervates, offering hierarchic
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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