Three-dimensional-printed silk fibroin scaffolds loaded with adipose-derived stem cells prevent post endoscopic submucosal dissection esophageal stricture in a porcine model.
Ye S., Zhang D., Shi X., Wang Z., Hu J., Zhao S.
Laboratory Study, published in Regen Biomater (2026) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Laboratory Study
- Journal
- Regen Biomater (2026)
- Country
- England
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 42077372
- PMCID
- PMC13135360
- DOI
- 10.1093/rb/rbag057
Abstract (original English)
Endoscopic submucosal dissection (ESD) is the preferred treatment for early esophageal cancer. However, extensive mucosal dissection frequently results in esophageal stricture. This study aimed to evaluate the efficacy of Three-dimensional (3D)-printed silk fibroin scaffolds (SFS) loaded with adipose-derived stem cells (ADSCs) in preventing post-ESD esophageal stricture, and to explore the underlying mechanisms. A near-circumferential ESD model was established in pigs, three groups were set: Control, SFS and ADSCs-SFS. The dynamic change of postoperative esophageal healing and stricture formation were monitored endoscopically. On postoperative Day 28, esophageal specimens were collected to measure mucosal contraction rate, followed by histological evaluation of inflammation and fibrosis, as well as mRNA transcriptome sequencing to analyze gene expression and the change of the enriched signaling pathways. On Day 28, the ADSCs-SFS group showed significantly less weight loss and a markedly reduced mucosal contraction rate. Histological examination revealed more complete mucosal regeneration and significantly reduced collagen deposition in the ADSCs-SFS group. Molecular analyses indicated significant downregulation of inflammatory and fibrotic markers in the ADSCs-SFS group. Transcriptome analysis suggested that ADSCs-loaded SFS effectively alleviates esophageal stricture following
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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