Tissue-Resident ILC2s Across Organs: Heterogeneity, Niche Crosstalk, and Shared Regulatory Circuits
Kim H., Lim J., Baek J., Van Dyken SJ., Kim DH.
Narrative Review, published in Immune Netw (2025) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Narrative Review
- Journal
- Immune Netw (2025)
- Reported sample size
- —
- Source database
- Europe PMC
- PMID
- 41523145
- PMCID
- PMC12780160
- DOI
- 10.4110/in.2025.25.e40
Abstract (original English)
Type 2 innate lymphoid cells (ILC2s) are an important source of innate cytokines that contribute to allergic inflammation. Recent studies have also suggested that ILC2s play a biological role in peripheral tissues such as lung, fat, intestine and skin, controlled by alarmins, neuropeptides and environmental factors. Furthermore, emerging studies have shown that tissues including the pancreas, uterus and meninges contain ILC2s that contribute to normal biological function. Here, we review recent studies on the physiological function of ILC2s in multiple tissues, emphasizing their importance not only in type 2 immune responses, but also in maintaining biological homeostasis.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is a narrative review: it collects no new patient data and does not systematically appraise evidence quality.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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