Titania nanotubes modified with copper enhance osteogenic differentiation of adipose derived stem cells.

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

To achieve long term success of orthopedic implants, it is critical to have a successful integration of bone and implant material. To accomplish this, various surface modifications have been investigated in research. Even though titania nanotubes and copper have individually demonstrated successful stem cell adhesion, proliferation and differentiation, these modifications have not yet been investigated together. In this study, we fabricated copper-modified titania nanotubes and evaluated the adhesion, proliferation and osteogenic differentiation of adipose derived stem cells on these surfaces. Implant surfaces also have to interact with blood after insertion in the body. Several studies have shown the importance of blood clots on material surfaces and their influence in differentiation of cells. Hence, blood clotting properties of modified surfaces were also investigated through whole blood clotting, and platelet adhesion and activation. The copper-modified titania nanotube surfaces demonstrated increased differentiation of adipose derived stem cells towards osteogenic lineage as well as enhanced blood clotting properties, thus they can be used as a potential surface for orthopedic implants.

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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