Total synthesis of albafuran B and its osteogenic differentiation promoting effect on human mesenchymal stem cells.
Liu WD., Jing Y., Wang B., Tian LL., Li J., Yin XS.
Laboratory Study, published in J Asian Nat Prod Res (2025) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Laboratory Study
- Journal
- J Asian Nat Prod Res (2025)
- Country
- England
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 40459846
- DOI
- 10.1080/10286020.2025.2509762
Abstract (original English)
In the current project, the total synthesis of albafuran B was achieved in four steps and 19.3% overall yield, involving two key reactions of the one-pot Corey-Fuchs reaction and Suzuki coupling. Using the same protocol, two analogs, moracin C and 4'-farnesyl-moracin M, were also successfully synthesized. The effect of albafuran B on the osteogenic differentiation of human umbilical cord-derived and adipose-derived mesenchymal stem cells was evaluated via alkaline phosphatase staining and alizarin red S staining. The assay results revealed that albafuran B showed good osteogenic differentiation promoting activity toward both cell lines.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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