Level D· Scientific groundwork from lab and animal studiesNarrative ReviewEurope PMC

Transcriptional control of brown fat development

Kajimura S., Seale P., Spiegelman BM.

Narrative Review, published in Cell Metab (2010) — summary generated from the PubMed abstract.

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Level D· Scientific groundwork from lab and animal studiesEvidence level of this study

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

  • Level A · Stronger Clinical Evidence
  • Level B · Emerging clinical evidence with positive signals
  • Level C · Early human research exploring benefits
  • Level D · Scientific groundwork from lab and animal studies
  • Emerging · Emerging topic under active research
Read the A–D evidence level guide

This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.

Study type
Narrative Review
Journal
Cell Metab (2010)
Reported sample size
—
Source database
Europe PMC
PMID
20374957
PMCID
PMC2857670
DOI
10.1016/j.cmet.2010.03.005
Citations
326

Abstract (original English)

Deconvoluting the natural pathway of BAT development has defined key molecular events, which enables researchers to manipulate the amount or activity of brown fat. We review recent advances on the transcriptional regulation of BAT development and discuss the emerging questions.

What this study does not prove

  • • This study does not prove SVF is an approved treatment or a replacement for standard care.
  • • This is a narrative review: it collects no new patient data and does not systematically appraise evidence quality.

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

How we grade evidence
HumansDNA-Binding ProteinsHeat-Shock ProteinsTranscription FactorsCell DifferentiationGene Expression RegulationThermogenesisModels, BiologicalForkhead Transcription FactorsAdipose Tissue, Brown

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