Transcriptome Analysis of Adipose Tissue Indicates That the cAMP Signaling Pathway Affects the Feed Efficiency of Pigs
Xu Y., Qi X., Hu M., Lin R., Hou Y., Wang Z.
Laboratory Study, published in Genes (Basel) (2018) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Laboratory Study
- Journal
- Genes (Basel) (2018)
- Reported sample size
- —
- Source database
- Europe PMC
- PMID
- 29973485
- PMCID
- PMC6070815
- DOI
- 10.3390/genes9070336
- Citations
- 30
Abstract (original English)
Feed efficiency (FE) is one of the main factors that determine the production costs in the pig industry. In this study, RNA Sequencing (RNA-seq) was applied to identify genes and long intergenic non-coding RNAs (lincRNAs) that are differentially expressed (DE) in the adipose tissues of Yorkshire pigs with extremely high and low FE. In total, 147 annotated genes and 18 lincRNAs were identified as DE between high- and low-FE pigs. Seventeen DE lincRNAs were significantly correlated with 112 DE annotated genes at the transcriptional level. Gene ontology (GO) analysis revealed that DE genes were significantly associated with cyclic adenosine monophosphate (cAMP) metabolic process and Ca 2+ binding. cAMP, a second messenger has an important role in lipolysis, and its expression is influenced by Ca 2+ levels. In high-FE pigs, nine DE genes with Ca 2+ binding function, were down-regulated, whereas S100G , which encodes calbindin D9K that serve as a Ca 2+ bumper, was up-regulated. Furthermore, ATP2B2 , ATP1A4 , and VIPR2 , which participate in the cAMP signaling pathway, were down-regulated in the upstream of lipolysis pathways. In high-FE pigs, the key genes involved in the lipid biosynthetic process ( ELOVL7 and B4GALT6 ), fatty acid oxidation ( ABCD2 and NR4A3 ), and lipid homeostasis ( C1QTNF3 and ABCB4 ) were down-regulated. These results suggested that cAMP was involved in the re
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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