Transdifferentiation and metaplasia--switching cell types.
Slack JM., Tosh D.
Narrative Review, published in Curr Opin Genet Dev (2001) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Narrative Review
- Journal
- Curr Opin Genet Dev (2001)
- Country
- England
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 11532402
- DOI
- 10.1016/s0959-437x(00)00236-7
Abstract (original English)
States of developmental commitment are encoded as combinations of transcription factors and changes in their expression can bring about transdifferentiation or metaplasia. For example, ectopic expressions of Vestigial can convert Drosophila leg to wing; of C/EBPbeta can convert pancreatic exocrine cells to hepatocytes; and expression of C/EBPalpha and PPARgamma can convert myoblasts to adipocytes.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is a narrative review: it collects no new patient data and does not systematically appraise evidence quality.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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