Treatment of Facial Asymmetry Caused by Parry-Romberg Syndrome Using Fat Transfer

Early human evidence such as case series or small samples is exploring possible benefits.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Parry-Romberg syndrome (PRS) is a rare craniofacial disorder marked by progressive unilateral facial atrophy. This case report presents a unique instance of PRS presenting in a 52-year-old female who was diagnosed at age 47 as the syndrome's usual onset is during the first two decades of life. The patient exhibited severe soft-tissue atrophy on the right side of the face, classified as type 3 PRS, along with associated symptoms such as headaches and a history of depression. The primary aesthetic intervention involved fat transfer (FT) to restore facial symmetry and contour. Postoperative outcomes improved facial aesthetics, though some volume loss was noted at the three-month follow-up. This case highlights the potential of FT as an effective and minimally invasive treatment for severe PRS. It emphasizes the importance of personalized treatment strategies and the need for further research into the long-term management of PRS, particularly in late-diagnosed cases. Further studies are needed to optimize fat grafting techniques and assess long-term outcomes in PRS management.

Evidence level

Early human evidence such as case series or small samples is exploring possible benefits.

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