Level C· Early human research exploring benefitsCohort StudyPubMed

Treatment of multiple chondral/osteochondral lesions in the knee of a juvenile athlete: A case report with literature review.

Leal DP., Mores V., Varone BB., Gobbi RG., Tirico LEP.

Cohort Study on Osteoarthritis, Cartilage Damage, published in J ISAKOS (2025) — summary generated from the PubMed abstract.

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Level C· Early human research exploring benefitsEvidence level of this study

Early human evidence such as case series or small samples is exploring possible benefits.

  • Level A · Stronger Clinical Evidence
  • Level B · Emerging clinical evidence with positive signals
  • Level C · Early human research exploring benefits
  • Level D · Scientific groundwork from lab and animal studies
  • Emerging · Emerging topic under active research
Read the A–D evidence level guide

This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.

Study type
Cohort Study
Journal
J ISAKOS (2025)
Country
England
Reported sample size
—
Source database
PubMed
PMID
41110704
DOI
10.1016/j.jisako.2025.100928

Abstract (original English)

Chondral and osteochondral lesions in the knee, particularly in juvenile athletes, pose significant challenges due to their impact on joint functionality and the complexity of treatment. This case report describes the management of a 14-year-old soccer athlete with osteochondritis dissecans of the lateral femoral condyle and a subsequent grade IV chondral lesion in the femoral trochlea. The initial treatment with fresh osteochondral transplantation resulted in osteointegration, pain resolution, and restored functionality. During rehabilitation, a secondary trochlear lesion developed and was treated with a combination of micro-fragmented autologous adipose tissue and a collagen membrane. The patient showed significant improvements in functional scores (Internation Knee Documentation Committee (IKDC), Knee Injury and Osteoarthritis Outcome Score (KOOS), Kujala, and Lysholm) and magnetic resonance imaging-confirmed cartilage regeneration and returned to sports-specific training. These findings highlight the potential of regenerative techniques for cartilage repair in young athletes. Further research is needed to validate these results in larger cohorts with extended follow-ups.

What this study does not prove

  • • This study does not prove SVF is an approved treatment or a replacement for standard care.

Evidence level

Early human evidence such as case series or small samples is exploring possible benefits.

How we grade evidence
HumansAdolescentMaleOsteochondritis DissecansMagnetic Resonance ImagingCartilage, ArticularSoccerKnee InjuriesTreatment OutcomeKnee Joint

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