TREM2 promotes adipogenesis of PDGFR-α + adipose stem cells but is dispensable for adipose remodeling and metabolic health during diet-induced obesity.
Dobrijevic A., Korosec A., Brunner JS., Matejovicova L., Gemza A., Lakovits K.
Animal Study, published in Front Endocrinol (Lausanne) (2026) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Animal Study
- Journal
- Front Endocrinol (Lausanne) (2026)
- Country
- Switzerland
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 42109717
- PMCID
- PMC13151143
- DOI
- 10.3389/fendo.2026.1738472
Abstract (original English)
White adipose tissue (WAT) expands through adipocyte hypertrophy or hyperplasia-associated differentiation of progenitor adipose stem cells (ASC). The triggering receptor expressed on myeloid cells 2 (TREM2) reportedly promotes adipocyte differentiation and whole body TREM2 deletion in mice leads to adipose hypertrophy and worsened metabolic health. However, whether TREM2 expression in ASC is involved is unknown. Here, we find TREM2 is expressed on platelet derived growth factor receptor-α (PDGFR-α) positive ASC in obesity. While global deletion of TREM2 strongly attenuated adipocyte differentiation in three different cell culture models, conditional TREM2 deletion within PDGFR-α + ASC impacted early adipocyte differentiation. Obese animals where TREM2 was specifically deleted in PDGFR-α + expressing cells exhibited moderately increased ASC, but WAT morphology, macrophage amounts as well as glucose and insulin tolerance were comparable to littermate controls. Thus, although TREM2 is important for adipocyte differentiation in cell culture, its expression in ASC is dispensable for WAT remodeling and metabolic health during obesity.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
How we grade evidenceBrowse all related research
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