UCP1 protein: The molecular hub of adipose organ plasticity.
Cinti S.
Narrative Review, published in Biochimie (2016) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Narrative Review
- Journal
- Biochimie (2016)
- Country
- France
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 27622583
- DOI
- 10.1016/j.biochi.2016.09.008
Abstract (original English)
In all mammals, adipocytes are cells with abundant cytoplasmic lipids forming the parenchyma of the adipose organ. White adipocytes store highly energetic molecules to release them, in the form of free fatty acids to survive between meals. Brown adipocytes trough their unique mitochondrial UCP1 protein burn glucose and lipids to perform thermogenesis in order to survive in cold environments. A third type of adipocytes appears in the subcutaneous depot of the adipose organ of female mice during pregnancy and lactation: the pink adipocytes. The pink adipocytes are mammary gland alveolar epithelial cells with the essential role of producing and secreting milk for pup feeding. Our data suggest that they derive from the transdifferentiation of white adipocytes. Different metabolic and environmental challenges highlight the extraordinary plasticity of the mammalian adipose organ. Cold exposure leads to an increase of the "brown" component of the adipose organ (browning) to warrant thermal homeostasis. Under positive energy balance, the "white" component enlarges (whitening) to allow storage of the excess of nutrients. Finally, during pregnancy the "pink" component develops (pinking) in the subcutaneous depots to satisfy pup nutritional needs. The plasticity of the adipose organ appears to occur not only through proliferation and differentiation of stem cells but, distinctively, via a
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is a narrative review: it collects no new patient data and does not systematically appraise evidence quality.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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