Unlocking the potential of stem cell-derived extracellular vesicles in osteoporosis therapy: a systematic review and meta-analysis of preclinical studies
Shuang F., Wen W., You Y., Zhang Y., Li H.
Meta-analysis, published in J Transl Med (2025) — summary generated from the PubMed abstract.
Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Meta-analysis
- Journal
- J Transl Med (2025)
- Reported sample size
- —
- Source database
- Europe PMC
- PMID
- 40533796
- PMCID
- PMC12178078
- DOI
- 10.1186/s12967-025-06654-5
- Citations
- 1
Abstract (original English)
Objective In recent years, stem cell-derived extracellular vesicles (SC-EVs) have garnered widespread attention for the treatment of osteoporosis. Based on all available data, we conducted a comprehensive evaluation of the efficacy of SC-EVs in preclinical studies, aiming to provide the latest evidence to support their clinical translation. Methods A comprehensive search was conducted in PubMed, Cochrane, Embase, and Web of Science databases for preclinical studies on SC-EVs for the treatment of osteoporosis, with the search period ending on November 10, 2024. Data extraction focused on three main aspects: general bone analysis parameters, histological quantification, and serum bone turnover markers. Additionally, the reporting quality and risk of bias of the studies were rigorously assessed. Results A total of 21 studies met the inclusion criteria and were included in the final meta-analysis. The results showed that SC-EVs treatment, compared to placebo, significantly increased bone mineral density, bone volume fraction, trabecular number, and trabecular thickness, while reducing trabecular separation. Furthermore, SC-EVs treatment promoted an increase in osteoblast numbers, inhibited osteoclast numbers, and enhanced bone mineralization. Despite the presence of heterogeneity and publication bias, the results were relatively robust. Conclusions Compared with placebo, SC-EV trea
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
Evidence level
Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.
How we grade evidenceBrowse all related research
Filter the research library by this study's title keywords, author, or publication year.