Unravelling the Efficacy of Internal Quilting Sutures vs Doxycycline Instillations in Preventing Seroma Formation After Gynecomastia Surgery
Ramasamy K., Alagarasan AR., Gupta H., Elangovan A., Thakkar Y., Silwal K.
Cohort Study, published in Aesthet Surg J Open Forum (2025) — summary generated from the PubMed abstract.
Early human evidence such as case series or small samples is exploring possible benefits.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Cohort Study
- Journal
- Aesthet Surg J Open Forum (2025)
- Reported sample size
- —
- Source database
- Europe PMC
- PMID
- 40008215
- PMCID
- PMC11852251
- DOI
- 10.1093/asjof/ojae078
- Citations
- 1
Abstract (original English)
Background Seroma frequently presents as a challenge, following gynecomastia correction surgery. This calls for percutaneous aspiration of accumulated fluid, from the iatrogenic dead space. The authors utilized internal quilting sutures and doxycycline instillation to analyze and compare their roles in seroma prevention. Objectives To compare the efficacy of intraoperative internal quilting sutures and doxycycline instillation, in preventing seroma formation and recurrence after gynecomastia surgery. Methods After local review board and ethics committee approval, the authors conducted this prospective single-center study of 120 gynecomastia patients with Rohrich's Grades I, II, and III, who underwent surgery between October 2023 and March 2024. Those belonging to Rohrich's Grade IV were excluded. Before surgery, the patients were divided into 3 cohorts of 40 individuals using a computerized randomization protocol. Cohort 1 underwent doxycycline instillation, Cohort 2 underwent internal quilting sutures, and no intervention was carried out in Cohort 3. Seroma diagnosis was confirmed clinically and the data were analyzed. All the patients were followed up for a month. Results The incidence of seroma formation, volume of seroma fluid removed, and the number of visits for seroma care were statistically found to be the least in the quilting group compared with the doxycycline and co
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
Evidence level
Early human evidence such as case series or small samples is exploring possible benefits.
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