Upper Eyelid Medial Fat Reduction and Pearl Grafting: A Modification and Review of Literature
Yao A., Malhotra R.
Retrospective Study with a reported sample of 60, published in Plast Reconstr Surg Glob Open (2025) — summary generated from the PubMed abstract.
Early human evidence such as case series or small samples is exploring possible benefits.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Retrospective Study
- Journal
- Plast Reconstr Surg Glob Open (2025)
- Reported sample size
- 60
- Source database
- Europe PMC
- PMID
- 41142879
- PMCID
- PMC12548986
- DOI
- 10.1097/gox.0000000000007173
Abstract (original English)
Background With age, there is a progressive volume disparity between the prominent medial fat pad and the atrophic central fat pad of the upper eyelid. We present a literature review of upper eyelid fat redistribution techniques and describe a novel postseptal medial fat pad pearl grafting technique as an adjunct to upper eyelid blepharoplasty. Methods Retrospective review was conducted of medial fat pad pearl grafting performed by a single surgeon between 2018 and 2024, with a minimum follow-up of 3 months. Medial and central fat pad volumes were graded by a masked observer using the Oh scale. Patient charts were assessed for adverse events such as irregularity, lipogranuloma formation, or revision surgery. Results A total of 60 patients underwent the procedure, of which 45 met the inclusion criteria (86 eyelids). The median age was 60 years (range 38-90 y), with 91.1% female patients. Follow-up was for an average of 8.2 months (range 3-40 mo). Adjunctive procedures included ptosis repair (41), lower blepharoplasty (16), and other (3). Central fat pad volumes significantly increased from an average grade of 0.92 preoperatively to 1.73 postoperatively ( P ≤ 0.05). Medial fat pad volumes significantly reduced from an average grade of 2.17 preoperatively to 1.77 postoperatively ( P ≤ 0.05). The procedure was well tolerated, and the central volume was well retained during the foll
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • Without an adequate control group, treatment effects cannot be separated from other factors.
Evidence level
Early human evidence such as case series or small samples is exploring possible benefits.
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