Urine-Derived Stem Cells: Applications of Paracrine-Driven Regeneration and Functional Recovery in Multiorgan Systems
Li D., Liang Z., Wang L., Chen Y., Sun D., Liang Y.
Narrative Review, published in Stem Cells Int (2026) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Narrative Review
- Journal
- Stem Cells Int (2026)
- Reported sample size
- —
- Source database
- Europe PMC
- PMID
- 42058469
- PMCID
- PMC13121925
- DOI
- 10.1155/sci/8089902
Abstract (original English)
Stem cell therapy, a highly recognized approach in the field of regenerative medicine, is known for its potential to stimulate the self-healing process of the body using stem cells or their derivatives, in which urine-derived stem cells (USCs) stand out as a novel and promising tool in treating various diseases recently. USCs are widely believed to derive primarily from glomerular parietal epithelial cells and podocytes and can be readily isolated from urine. Owing to telomerase-associated self-renewal capacity, USCs proliferate efficiently in vitro, while their outstanding differentiation potential and paracrine effects support promising applications in tissue regeneration and functional recovery. The extracellular particles (EPs) of USCs, including various activity factors, exosomes, and other extracellular vesicles (EVs), play significant roles in the paracrine effects of USCs, which have gained recognition as pivotal factors in the therapeutic studies of USCs. USCs-EPs can affect on diseases in different organ systems through various mechanisms, in which cell differentiation, angiogenesis, and cell proliferation and migration are the three mainly affected functions. And the USCs-EPs may play dual roles based on different curative effects. Besides, the varied modification and encapsulation of USCs-EPs may promote their therapeutic effects. Up to now, USCs-EPs have been widel
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is a narrative review: it collects no new patient data and does not systematically appraise evidence quality.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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