[Use of mesenchymal stemcells in dogs].

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Mesenchymal stem cells (MSC) are multipotent cells, which are able to differentiate into various cell types of the body, as for example in osteogenic, chondrogenic, adipogenic and myogenic directions. In human medicine, the application of stem cells represents a well-established clinical procedure already applied for several decades. Addition-ally, in veterinary medicine, the stem-cell field is a rapidly growing sector for clinical use, particularly in horses. Recently, this treatment moda lity has also been commonly applied in dogs. The main field of application are diseases of the musculoskeletal system. Furthermore MSC are predominantly used for the treatment of lameness because of osteoarthritic changes of the large joints. In veterinary medicine, MSC are mainly isolated from bone marrow or adipose tissue. This artic le provides an overview of the removal site, isolation, characterisation and application of MSC. Moreover, studies available in the litera ture concerning the therapy of orthopaedic diseases in the dog using MSC are presented.

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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