[The use of stem cells to stimulate regeneration of damaged nerve].

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

The purpose of the review was the summation of the results of experimental studies on the use of stem cells to repair damaged nerves. There are two basic strategies to connect the segment of nerve damage: the use of biodegradable scaffolds and conduits and the application of stem cells. Stem cells are source of the growth and trophic factors. Embryonic stem cells, neural stem/progenitor cells, olfactory ensheathing cells, mesenchymal stem cells, adipose-derived stem cells, dental pulp stem cells, skin-derived precursor cells were used in the past ten years. Genetically modified cells with overexpression of growth factors were also used. Analysis of the results of experimental studies have shown that stem cells contribute to improving the recovery of damaged nerves. Further basic research on the mechanisms of the influence of the transplanted stem cells in regenerating axons and Schwann cells of the recipient are required. Investigation of the fate of transplanted cells in the long-term after the operation is necessary to eliminate the risk of any adverse effects of stem cell transplantation. The use of stem cells in experimental modeling of nerve injury allows us to study patterns of development of stem cells, mechanisms of their differentiation and malignant transformation.

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

Browse all related research

Filter the research library by this study's title keywords, author, or publication year.