Vitamin-Conjugated Metallic Nanoparticles: Applications for Antimicrobial and Anti-Cancer Drug Delivery

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Vitamin-conjugated metallic nanoparticles (VC-MNPs) have emerged as a transformative platform in nanomedicine that combine the therapeutic potential of vitamins with the structural versatility of metal nanoparticles. They offer a dual advantage of targeted drug delivery and enhanced therapeutic efficacy, enabling precise intervention against infectious and malignant diseases. Vitamin conjugation facilitates receptor-mediated targeting, antioxidant enhancement, and improved biocompatibility, thereby strengthening therapeutic outcomes and reducing off-target effects. This review critically evaluates how vitamin functionalization modulates the synthesis, activity, and clinical translation of VC-MNPs. Diverse synthesis methods including chemical reduction, co-precipitation, sol-gel, and green approaches are evaluated, along with the influence of synthesis parameters on nanoparticle performance. The mechanisms underlying enhanced antimicrobial and anti-cancer efficacy are discussed, highlighting the contributions of vitamin functionalization to cellular uptake, redox balance and metabolic selectivity. Critical challenges in clinical translation are systematically assessed, including nanoparticle stability under physiological conditions, potential toxicity concerns, regulatory approval pathways, and manufacturing scalability requirements. Finally, the paper considers future perspecti

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

Browse all related research

Filter the research library by this study's title keywords, author, or publication year.