In Vivo Assessment of Plasma Gel: Regenerative Potential and Limitations as a Filler

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Background Plasma gel, also known as plasma-rich in growth factors (PRGF) gel or platelet-rich gel, is a novel application of platelet-rich plasma (PRP), created by heating platelet-poor plasma (PPP) to induce denaturation, forming a gel-like substance. This gel is then combined with PRP to create a new injectable biomaterial that offers both the regenerative benefits of PRP and structural support due to its gel-like consistency. Plasma gel has been increasingly used not only for its biological regenerative properties but also as a cosmetic filler to enhance tissue volume and improve skin aesthetics. It shows promise in facial rejuvenation by improving skin texture and elasticity, and reducing the appearance of wrinkles. However, the detailed in vivo behavior of plasma gel, particularly its absorption rate and regenerative efficacy, remains underexplored. Aims This study aims to investigate the in vivo behavior of plasma gel, focusing on its absorption rate and its ability to stimulate tissue regeneration. Specifically, we aim to assess how quickly plasma gel is absorbed after subcutaneous injection and to evaluate its effects on collagen production and neovascularization using a nude mouse model. Methods Plasma gel was prepared by heating PPP to create a gel-like substance, which was then mixed with PRP. This mixture was injected subcutaneously into nude mice. The absorption o

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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