Vocal fold augmentation with autologous fat following transoral laryngeal surgery.

Early human evidence such as case series or small samples is exploring possible benefits.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Transoral laryngeal surgery (TOLS) may lead to glottic insufficiency and scarring which often causes pronounced hoarseness and sometimes swallowing impairment. Injection laryngoplasty with autologous fat is an established method to restore glottic competence and thus improve voice and swallowing function. We hereby aim to demonstrate how laryngeal fat injection can be applied following TOLS. Autologous fat is harvested via liposuction and then centrifuged for three minutes at 3000 rpm (rpm) to separate fat cells from liquid fat and debris. Fat cells are then transferred to 1 ml Luer-Lock syringes and injected into the altered larynx via a 20 Gauge (0,9 mm) diameter injection needle under microscopic or endoscopic view. The primary objective hereby is approximation of remaining tissue on the glottic plain. The secondary objective is injection into areas of scarified tissue due to the beneficial effect of Adipose-Derived Mesenchymal Stem Cells and possible restoration of physiological laryngeal tissue properties. Injection laryngoplasty with autologous fat tissue may improve laryngeal function after partial laryngeal resection by laser surgery. Special attention needs to be paid to the specific individual postoperative anatomy of the patient's larynx as this may differ profoundly from patient to patient. 1. Hoarseness after transoral laser surgery of the larynx is often caused by

Evidence level

Early human evidence such as case series or small samples is exploring possible benefits.

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