Water contact angle data and FTIR data of stem cell/tenocyte co-culture-derived secretome releasing electrospun tube; and adhesion data of fully transected and sutured rabbit Achilles tendons three weeks post-operation u

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Tendon ruptures may result in unsatisfactory outcomes, even after long rehabilitation programs and careful return to daily activities and sports. One major problem after a tendon rupture is the fibrotic adhesion formation to the adjacent tissue, which hampers proper motion and may end up in a permanent reduced range of motion. Following a cell-free approach, we cultivated rabbit adipose-derived stem cells (ASCs) and rabbit Achilles tenocytes in a ratio of 3:1 and incorporated the secretome harvested from this co-culture into an emulsion electrospun tubular DegraPol® fiber mesh. These tubes were characterized by thestatic and dynamic water contact angles and by FTIR spectra, with a comparison to tubes without secretome incorporation (control). Furthermore, we present adhesion data from an in vivo experiment, where these tubes were implanted around a fully transected rabbit Achilles tendon after suture at 3 weeks post-operation.

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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