Weight Loss and Its Impact on Soft Tissue.
Fathizadeh S., Palm MD., Hooper D.
Narrative Review, published in J Drugs Dermatol (2026) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Narrative Review
- Journal
- J Drugs Dermatol (2026)
- Country
- United States
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 42081631
- DOI
- 10.36849/JDD.9532
Abstract (original English)
Rapid and intentional weight loss can result from bariatric surgery, pharmacologic agents such as glucagon-like peptide-1 receptor agonists, and intensive lifestyle changes. Although effective in lowering body weight, these interventions often produce broader physiologic effects. Patients may experience changes beyond size, including decreased skin firmness, muscle loss, and reduced bone density. To describe the dermatologic and structural consequences of rapid weight loss and review current and emerging management strategies. A narrative review was conducted using PubMed and Google Scholar to identify English-language literature published between 2000 and 2025 on soft tissue changes associated with rapid weight loss. Rapid weight loss impacts collagen, elastic fibers, adipose tissue, muscle mass, and skeletal integrity. Management strategies include nutritional optimization, resistance-based physical activity, energy-based devices, biostimulatory injectables, and, in advanced cases, surgical procedures. Regenerative therapies are also under investigation. As rapid weight loss becomes increasingly common, dermatologists are encountering a broader range of cosmetic and structural concerns. A multidisciplinary, evidence-informed approach is critical for addressing these issues and improving patient outcomes.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is a narrative review: it collects no new patient data and does not systematically appraise evidence quality.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
How we grade evidenceBrowse all related research
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