Zeta PKC in rat preadipocytes: modulation by insulin and serum mitogenic factors and possible role in adipogenesis.
Lacasa D., Agli B., Giudicelli Y.
Animal Study, published in Biochem Biophys Res Commun (1995) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Animal Study
- Journal
- Biochem Biophys Res Commun (1995)
- Country
- United States
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 8526899
- DOI
- 10.1006/bbrc.1995.2753
Abstract (original English)
Several PKC isoforms belonging to the three PKCs' subfamilies cPKC alpha and beta isoforms, nPKC epsilon isoform and aPKC zeta isoform were detected by Western blot in rat preadipocytes. zeta PKC which appears involved in proliferation and differentiation of some cellular types was shown to display variations according to the preadipocyte anatomical origin and stage of differentiation. A rapid increase in zeta PKC in the cytosolic compartment and translocation into the nucleus were induced by mitogenic factors in proliferating preadipocytes and by insulin in differentiating preadipocytes. These findings suggest that zeta PKC could be involved i) in the post-receptor signaling pathway of serum mitogenic factors and insulin in preadipocytes, and ii) in the mechanisms underlying the variations in the proliferating and differentiating capacities of preadipocytes according to their anatomical localization.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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