Emerging· Emerging topic under active research
Efficacy and safety of autologous adipose tissue-derived stromal vascular fraction in patients with premature ovarian insufficiency: protocol for a single-centre randomised controlled trial
Zhang Y., Liu H., Lou Y., Qiao J.
A pre-published randomized trial protocol testing SVF in premature ovarian insufficiency — no results yet.
Emerging· Emerging topic under active researchEvidence level of this study
Currently limited data exists for this topic; researchers are continuing to study it to understand future benefit and safety.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
- Study type
- Clinical Trial
- Journal
- BMJ Open (2025)
- Country
- China
- Sample size
- —
- Follow-up
- As specified in the protocol
- PMID
- 40180397
- DOI
- 10.1136/bmjopen-2024-093804
What was studied
A plan to test whether SVF can restore ovarian function in POI patients.
Methods
- • Single-centre randomized controlled trial; protocol only at publication.
Key findings
- • No outcome data — this is a protocol publication.
Limitations
- • No patient data, so it cannot inform treatment decisions.
What this study does not prove
- • The existence of a protocol does not indicate the therapy works or is safe.
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • Limited follow-up cannot indicate long-term outcomes.
Clinical interpretation
Signals an active research direction, not evidence supporting treatment.
Evidence level: Emerging topic under active research