Condition
Ankle Injury
Focused on talar osteochondral lesions.
Quick summary
- • Usually combined with arthroscopic surgery
Overview
Ankle cartilage lesions often require surgery, with cell augmentation under study.
Mechanisms studied
Studied for lesion fill and repair-tissue quality.
Human research
AOFAS scores reported at medium-term follow-up.
Safety
Reported adverse events are mostly local — swelling, pain, or bruising at the harvest and injection sites. Infection and cell-processing quality remain the key risks to monitor.
Evidence limitations
Existing studies are limited by sample size, methodology, and follow-up, and SVF preparation differs substantially between centres, making cross-study comparison difficult.
Related research
Latest PubMed research
91 indexed studies for this condition · auto-updated 17 August 2026
- Level ASystematic ReviewPubMed
Cell-Based Therapies for Post-Traumatic Ankle Osteoarthritis and Osteochondral Lesions of the Talus: A Systematic Scoping Review of an Emerging and Heterogeneous Evidence Base.
Systematic Review on Knee Osteoarthritis, Osteoarthritis, Cartilage Damage, Ankle Injury, published in Bioengineering (Basel) (2026) — summary generated from the PubMed abstract.
- 2026
Bioengineering (Basel) - Level ASystematic ReviewPubMed
Platelet-Rich Plasma Injections for Foot and Ankle Pathologies Have Significantly More Complications Compared With Hyaluronic Acid Injections, Saline Solution Injections, and Dry Needling: A Systematic Review.
Systematic Review with a reported sample of 674 on Osteoarthritis, Cartilage Damage, Tendon Injury, Ankle Injury, published in Arthroscopy (2025) — summary generated from the PubMed abstract.
- 2025
- n = 674
Arthroscopy1 citations - Level ASystematic ReviewEurope PMC
Operative management of osteochondral lesions of the talus: 2024 recommendations of the working group 'clinical tissue regeneration' of the German Society of Orthopedics and Traumatology (DGOU)
Systematic Review on Cartilage Damage, Ankle Injury, published in EFORT Open Rev (2024) — summary generated from the PubMed abstract.
- 2024
EFORT Open Rev23 citations - Level AMeta-analysisPubMed
Therapeutic Effect of Stem Cells from Different Sources on Diabetic Foot Ulcers: Systematic Review and Network Meta-Analysis.
Meta-analysis on Ankle Injury, Diabetic Foot, Chronic Wound, published in Int J Low Extrem Wounds (2024) — summary generated from the PubMed abstract.
- 2024
Int J Low Extrem Wounds - Level ASystematic ReviewEurope PMC
Visualized trends and bibliometric analysis in ankle cartilage repair from 2004 to 2024
Systematic Review on Cartilage Damage, Ankle Injury, published in Front Med (Lausanne) (2024) — summary generated from the PubMed abstract.
- 2024
Front Med (Lausanne) - Level ASystematic ReviewPubMed
Adipose-derived stem cells applied to ankle pathologies: a systematic review.
Systematic Review on Osteoarthritis, Cartilage Damage, Ankle Injury, Scar, published in Musculoskelet Surg (2023) — summary generated from the PubMed abstract.
- 2023
Musculoskelet Surg2 citations
Last updated: 2026-06-18 · arisa-w