Condition
Chronic Wound
Multiple human studies report wound-closure rates.
Quick summary
- • Some controlled clinical trials exist
- • Results differ by wound type
Overview
Chronic wounds include diabetic, pressure, and venous ulcers.
Mechanisms studied
Studied for angiogenesis and fibroblast migration.
Human research
Closure rates and healing times are reported.
Safety
Reported adverse events are mostly local — swelling, pain, or bruising at the harvest and injection sites. Infection and cell-processing quality remain the key risks to monitor.
Evidence limitations
Existing studies are limited by sample size, methodology, and follow-up, and SVF preparation differs substantially between centres, making cross-study comparison difficult.
Related research
- Level BMeta-analysis
Efficacy of stromal vascular fraction in the treatment of scars: A systematic review and meta-analysis
Pooled four studies with 145 patients (64 receiving SVF): significant benefit for vascularity, itching, POSAS and scar thickness.
- 2024
- China
- n = 145
- Level CSystematic Review
A systematic review of autologous adipose-derived stromal vascular fraction (SVF) for the treatment of acute cutaneous wounds
Evaluated the literature on efficacy and safety of autologous SVF for acute cutaneous wounds in humans.
- 2022
- United States
- Level BMeta-analysis
The efficiency of human fat products in wound healing: A systematic review and meta-analysis
Pooled 21 RCTs of autologous fat, SVF or ADSCs, finding faster healing rate, shorter healing time and more complete healing versus conventional treatment.
- 2024
- China
- EmergingLaboratory Study
Therapeutic application of adipose-derived stromal vascular fraction in diabetic foot
Review describing diabetic foot pathogenesis, current treatments, and vascular remodelling as the proposed mechanism behind SVF effects.
- 2020
- China
- Level BSystematic Review
Comparing mechanical and enzymatic isolation procedures to isolate adipose-derived stromal vascular fraction: A systematic review
Reviewed 26 articles covering 33 SVF isolation procedures (11 enzymatic, 22 mechanical): comparable cell yield and viability, but mechanical methods were faster and cheaper.
- 2024
- Netherlands
Latest PubMed research
4,072 indexed studies for this condition · auto-updated 17 August 2026
- Level AMeta-analysisEurope PMC
Efficacy and Safety of Fat Graft Myringoplasty Combined With Platelet-Rich Plasma for Managing Chronic Tympanic Membrane Perforations: A Systematic Review and Meta-Analysis
Meta-analysis with a reported sample of 522 on Chronic Wound, published in Clin Exp Otorhinolaryngol (2026) — summary generated from the PubMed abstract.
- 2026
- n = 522
Clin Exp Otorhinolaryngol1 citations - Level ASystematic ReviewEurope PMC
Stem cell-derived exosomes in tissue regeneration of oral and maxillofacial region: A systematic review
Systematic Review on Chronic Wound, published in Medicine (Baltimore) (2026) — summary generated from the PubMed abstract.
- 2026
Medicine (Baltimore) - Level ASystematic ReviewEurope PMC
Best evidence summary for platelet-rich plasma treatment of chronic wounds
Systematic Review on Chronic Wound, published in Regen Ther (2026) — summary generated from the PubMed abstract.
- 2026
Regen Ther - Level ASystematic ReviewEurope PMC
Dedifferentiation of Mature Adipocytes and Their Future Potential for Regenerative Medicine Applications
Systematic Review on Type 2 Diabetes, Chronic Wound, published in Biomedicines (2026) — summary generated from the PubMed abstract.
- 2026
Biomedicines - Level AMeta-analysisEurope PMC
Effect of stem cell therapies on tendon-bone healing after anterior cruciate ligament reconstruction in animal models: Protocol for a systematic review and meta-analysis
Meta-analysis on Tendon Injury, Ligament Injury, Chronic Wound, published in PLoS One (2026) — summary generated from the PubMed abstract.
- 2026
PLoS One1 citations - Level AMeta-analysisEurope PMC
Therapeutic value of mesenchymal stem cell-derived extracellular vesicles in hypertrophic and keloid scars: a systematic review and meta-analysis
Meta-analysis on Chronic Wound, Scar, published in Front Cell Dev Biol (2026) — summary generated from the PubMed abstract.
- 2026
Front Cell Dev Biol
Last updated: 2026-06-18 · arisa-w