Condition
Facial Rejuvenation
Focused on fat-graft retention and skin quality.
Quick summary
- • Cell-assisted lipotransfer is a common research term
Overview
This research area is closer to plastic surgery than internal medicine.
Mechanisms studied
Survival of grafted adipose tissue is studied.
Human research
Small RCTs compare with fat grafting alone.
Safety
Reported adverse events are mostly local — swelling, pain, or bruising at the harvest and injection sites. Infection and cell-processing quality remain the key risks to monitor.
Evidence limitations
Existing studies are limited by sample size, methodology, and follow-up, and SVF preparation differs substantially between centres, making cross-study comparison difficult.
Related research
- Level BMeta-analysis
Stromal Vascular Fraction-Assisted Fat Grafting: A Systematic Review and Meta-analysis of Clinical Outcomes
Meta-analysis comparing SVF-enriched fat grafting with conventional technique, assessing graft retention and safety.
- 2026
- Saudi Arabia
- Level BMeta-analysis
Cell-assisted lipotransfer: Friend or foe in fat grafting? Systematic review and meta-analysis
Included 25 studies with 696 patients; fat survival rate was significantly higher with cell-assisted lipotransfer than conventional grafting.
- 2018
- France
- n = 696
- Level BMeta-analysis
Efficacy and Safety of Cell-Assisted Lipotransfer: A Systematic Review and Meta-Analysis
Pooled 17 articles covering 387 cases to estimate fat survival rate along with complication and reoperation incidence.
- 2016
- China
- n = 387
- Level CSystematic Review
Potential drawbacks in cell-assisted lipotransfer: A systematic review of existing reports
Reviewed 57 CAL studies focusing on drawbacks and risks such as graft liquefaction/resorption and the absence of standardised guidelines.
- 2016
- China
- Level DCase Series
Nanofat grafting: basic research and clinical applications
Reports 67 clinical cases of nanofat for superficial rhytides, scars and dark lower eyelids, plus analysis of the cellular content of processed fat.
- 2013
- Belgium
- n = 67
Latest PubMed research
305 indexed studies for this condition · auto-updated 17 August 2026
- Level AMeta-analysisPubMed
Clinical Efficacy of Adipose-Derived Stem Cell-Enriched Lipotransfer Versus Conventional Fat Grafting: A Systematic Review and Meta-Analysis.
Meta-analysis on Facial Rejuvenation, published in Cureus (2026) — summary generated from the PubMed abstract.
- 2026
Cureus - Level ASystematic ReviewPubMed
A commentary on the need for minimum information for studies evaluating biologics in plastic surgery.
Systematic Review on Chronic Wound, Facial Rejuvenation, published in J Plast Reconstr Aesthet Surg (2026) — summary generated from the PubMed abstract.
- 2026
J Plast Reconstr Aesthet Surg - Level ASystematic ReviewEurope PMC
Autolougous platelet concentrates in esthetic medicine
Systematic Review on Scar, Skin Aging, Facial Rejuvenation, Hair Regeneration, published in Periodontol 2000 (2025) — summary generated from the PubMed abstract.
- 2025
Periodontol 200016 citations - Level ASystematic ReviewEurope PMC
The Role of Platelet Concentrates and Growth Factors in Facial Rejuvenation: A Systematic Review with Case Series
Systematic Review on Skin Aging, Facial Rejuvenation, published in Medicina (Kaunas) (2025) — summary generated from the PubMed abstract.
- 2025
Medicina (Kaunas)5 citations - Level AMeta-analysisPubMed
A Systematic Review of Adipose-Derived Cell Therapies on Skin Quality.
Meta-analysis on Skin Aging, Facial Rejuvenation, published in Aesthet Surg J Open Forum (2025) — summary generated from the PubMed abstract.
- 2025
Aesthet Surg J Open Forum1 citations - Level ASystematic ReviewEurope PMC
A Systematic Review of Platelet-Rich Plasma Versus Platelet-Rich Fibrin for Periorbital Rejuvenation
Systematic Review on Skin Aging, Facial Rejuvenation, published in J Cosmet Dermatol (2025) — summary generated from the PubMed abstract.
- 2025
J Cosmet Dermatol2 citations
Last updated: 2026-06-18 · arisa-w