Condition
Scar
Research on scar quality and skin texture.
Quick summary
- • Outcomes are often measured with subjective scales
Overview
Atrophic and hypertrophic scars are studied differently.
Mechanisms studied
Collagen remodelling is studied.
Human research
Case series and small studies exist.
Safety
Reported adverse events are mostly local — swelling, pain, or bruising at the harvest and injection sites. Infection and cell-processing quality remain the key risks to monitor.
Evidence limitations
Existing studies are limited by sample size, methodology, and follow-up, and SVF preparation differs substantially between centres, making cross-study comparison difficult.
Related research
- Level BMeta-analysis
Stromal Vascular Fraction-Assisted Fat Grafting: A Systematic Review and Meta-analysis of Clinical Outcomes
Meta-analysis comparing SVF-enriched fat grafting with conventional technique, assessing graft retention and safety.
- 2026
- Saudi Arabia
- Level BMeta-analysis
Efficacy of stromal vascular fraction in the treatment of scars: A systematic review and meta-analysis
Pooled four studies with 145 patients (64 receiving SVF): significant benefit for vascularity, itching, POSAS and scar thickness.
- 2024
- China
- n = 145
- Level BProspective Study
Efficacy and safety of stromal vascular fraction on scar revision surgery: a prospective study
Prospective double-blind study in 20 patients comparing an SVF-injected side with a saline-injected side of the same scar.
- 2023
- South Korea
- n = 20
- Level DCase Series
Nanofat grafting: basic research and clinical applications
Reports 67 clinical cases of nanofat for superficial rhytides, scars and dark lower eyelids, plus analysis of the cellular content of processed fat.
- 2013
- Belgium
- n = 67
- Level CSystematic Review
A systematic review of autologous adipose-derived stromal vascular fraction (SVF) for the treatment of acute cutaneous wounds
Evaluated the literature on efficacy and safety of autologous SVF for acute cutaneous wounds in humans.
- 2022
- United States
- Level BSystematic Review
Comparing mechanical and enzymatic isolation procedures to isolate adipose-derived stromal vascular fraction: A systematic review
Reviewed 26 articles covering 33 SVF isolation procedures (11 enzymatic, 22 mechanical): comparable cell yield and viability, but mechanical methods were faster and cheaper.
- 2024
- Netherlands
Last updated: 2026-06-18 · arisa-w