2(3→20)-abeo-taxoids with adipogenesis inhibitory activity from the leaves and twigs of Taxus chinensis var. mairei.

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Phytochemical investigation of the leaves and twigs of Taxus chinensis var. mairei yielded seven previously undescribed taxane diterpenoids (1-7). Their structures were elucidated through comprehensive spectroscopic analysis, electronic circular dichroism calculations, and single-crystal X-ray diffraction. Compounds 1-4 were characterized as 2(3→20)-abeo-taxoids with extended conjugation, while 7 was distinguished by a rare α-substituted cinnamoyloxy moiety. All compounds were evaluated for their inhibitory effects on adipogenesis in 3T3-L1 adipocytes. Among them, compounds 4 and 5 exhibited significant triglyceride-lowering activity, with IC 50 values of 4.42 ± 0.19 μM and 5.44 ± 0.58 μM, respectively, demonstrating superior potency compared to the positive agent fenofibrate.

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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