Acute Onset of Mesoamerican Nephropathy in a Patient With Chronic Gout and Occupational Exposure: A Case Report

Early human evidence such as case series or small samples is exploring possible benefits.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Mesoamerican nephropathy (MeN) is a form of chronic kidney disease that is becoming increasingly prevalent. Multiple risk factors, including male gender, exposure to pesticides, heat stress, use of nephrotoxic medications, and a geographical association with Central America, have been linked to this condition. We present the case of a 40-year-old male from El Salvador who sought medical attention due to abnormal laboratory results and a flare-up of gout. The patient exhibited elevated creatinine and blood urea nitrogen (BUN) levels, with a significantly reduced glomerular filtration rate (GFR). His renal function had been stable three months earlier, when he had established care with his primary care physician. The patient had a history of agricultural work in El Salvador, along with long-term use of colchicine and nonsteroidal anti-inflammatory drugs (NSAIDs) for gout flare-ups. Following consultation with nephrology, he was diagnosed with MeN due to his relevant risk factors and clinical presentation. This case highlights the acute onset of MeN in a patient with established risk factors.

Evidence level

Early human evidence such as case series or small samples is exploring possible benefits.

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